Thermodynamic analysis of the interactions between human ACE2 and spike RBD of Betacoronaviruses (SARS-CoV-1 and SARS-CoV-2)Article Published on 2023-01-012023-07-10 Journal: FEBS Open Bio [Category] COVID19(2023년), [키워드] binding interactions human ACE2 isothermal titration alorimetry receptor-binding domain. SARS-CoV-1 SARS-CoV-2 [DOI] 10.1002/2211-5463.13525 PMC 바로가기
Structure and inhibition of SARS-CoV-1 and SARS-CoV-2 main proteases by oral antiviral compound AG7404Article Published on 2022-12-012023-07-10 Journal: Antiviral Research [Category] COVID19(2023년), [키워드] AG7404 Human coronavirus Main protease M(pro) Rupintrivir SARS-CoV-1 SARS-CoV-2. [DOI] 10.1016/j.antiviral.2022.105458 PMC 바로가기
Coronavirus Antibody Responses before COVID-19 Pandemic, Africa and ThailandArticle Published on 2022-11-012022-11-15 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Affect Africa Antibody Response Antigen collected coronavirus coronavirus coronavirus disease Coronaviruses country COVID-19 COVID-19 pandemic distribution Endemic HIV-1 human SARS-CoV-2 IgG response immune response Kenya less Middle East monoclonal antibody much higher Nigeria nucleocapsid protein participant Participants populations Profiling Protein respiratory infections respiratory syndrome coronavirus response SARS SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike screened Serosurvey serum and plasma severe acute respiratory syndrome coronavirus 2 significantly more subunit tested Thailand the receptor-binding domain Uganda Vaccine viruses zoonoses zoonoses. [DOI] 10.3201/eid2811.221041 PMC 바로가기
Antibody and T-cellular response to COVID-19 booster vaccine in SARS-CoV-1 survivorsArticle Published on 2022-11-012022-11-15 Journal: Clinical immunology (Orlando, Fla.) [Category] SARS, 진단, [키워드] acute respiratory syndrome Antibody titer Beta booster booster vaccination Booster vaccine CD4 CD8 comparable coronavirus COVID-19 Delta dose effective elicit elicited generate healthy individual humoral immune response less MOST naïve neutralization neutralizing antibody omicron robust SARS-CoV-1 SARS-CoV-1 survivors SARS-CoV-2 survivor Survivors T cell response T cell responses T-cell Response T-cell response. WA1 while Wuhan-Hu-1 [DOI] 10.1016/j.clim.2022.109103 PMC 바로가기
An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motifArticle Published on 2022-10-282022-11-15 Journal: Science Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 receptor acute respiratory syndrome antibody Beta binding conserved coronavirus cryo-EM structure Delta delta variant demonstrated develop DNA epitope Evolution glycosylation site identify immune lung mice neutralize neutralizing activities omicron RBD Receptor binding domain receptor binding motif reduced SARS coronavirus SARS coronaviruses SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2-specific B cell sequenced single-cell the RBD therapeutic variant Viral load viral spike protein were infected [DOI] 10.1126/sciimmunol.abp9962 PMC 바로가기
Priming conditions shape breadth of neutralizing antibody responses to sarbecovirusesArticle Published on 2022-10-212022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] BNT162b2 BNT162b2 vaccine breadth Breakthrough infection Cohort Combination condition cross-neutralization cross-protective dose elicit highest immunized inactivated include individual Infection magnitude mRNA multiplex neutralization Neutralization assay neutralizing antibody Neutralizing antibody response of BNT162b2 omicron public health Receptor binding domain sarbecovirus sarbecovirus Sarbecoviruses SARS-CoV-1 SARS-CoV-1 infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sera Sinopharm vaccination Vaccine Vaccine design Virus spike viruses [DOI] 10.1038/s41467-022-34038-6 PMC 바로가기
Broad Tricyclic Ring Inhibitors Block SARS-CoV-2 Spike Function Required for Viral EntryArticle Published on 2022-10-142022-11-16 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome affected angiotensin-converting enzyme 2 binding binding pocket block blocked broad inhibitor candidate cell-cell fusion cellular circulating SARS-CoV-2 variant Compound conformational change conserved coronavirus Critical Entry inhibitor entry inhibitors entry pathway facilitate function glycoprotein host cell Infection inhibitory effect interfere mode of action plasma membrane receptor Receptor binding domain required Ring SARS-CoV SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike selective significantly Small molecules spike Spike. subsequent tested the SARS-CoV-2 these compound Tricyclic Trigger viral entry viral spike [DOI] 10.1021/acsinfecdis.1c00658 PMC 바로가기
Theoretical investigation on the interactions of microplastics with a SARS-CoV-2 RNA fragment and their potential impacts on viral transport and exposureSARS-CoV-2 RNA 단편과 미세 플라스틱의 상호 작용 및 바이러스 수송 및 노출에 대한 잠재적 영향에 대한 이론적 조사Article Published on 2022-10-102022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affinity Behavior Behavior and fate cause condition coronavirus coronavirus disease Coronavirus disease-19 COVID-19 determine electrostatic environmental conditions Environmental pollution Evidence exposure to facilitate FIVE greater HBV hepatitis B Hepatitis B virus Human hydrophobic Impact independent independent of inherent Interaction involved Lungs mechanism media Microplastic pollution microplastics molecular molecular dynamic simulations molecular interaction molecular volume Nucleic acid material pandemic pandemic spread parameter polar risk RNA RNA fragment SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 transmission SARS-CoV-2. severe acute respiratory syndrome Coronavirus Spread strong interaction surface area temperature the SARS-CoV-2 Transport vacuum virus water [DOI] 10.1016/j.scitotenv.2022.156812 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Papain-Like Protease: Structure, Function and InhibitionArticle Published on 2022-10-062022-11-15 Journal: Chembiochem [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] antiviral agent antiviral immune response antivirals coronavirus COVID-19 derivatives Epidemic function Host immune response immune immune response in viral inhibition involved ISG15 less MERS-CoV motif other coronaviruses Papain-like protease posttranslational modifications protease protease inhibitors protease inhibitors. Replication SARS-CoV-1 SARS-CoV-2 Structure targets variants of concern variants of SARS-CoV-2 Viral protein [DOI] 10.1002/cbic.202200327 PMC 바로가기
A research and development (R&D;) roadmap for broadly protective coronavirus vaccines: Setting a path to address coronavirus threatsArticle Published on 2022-10-062023-07-10 Journal: Vaccine [Category] COVID19(2023년), [키워드] Broadly protective coronavirus vaccines coronavirus COVID-19 MERS-CoV pandemic preparedness Roadmap SARS-CoV-1 SARS-CoV-2. [DOI] 10.1016/j.vaccine.2022.08.071 PMC 바로가기